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This work offers a broadly applicable design route for the development of advanced catalysts with an outstanding combination of activity and reusability for wastewater treatments.Cyclic peptides (CPs) have attracted attention as next-generation drugs because they possess both cell-permeable potential as small molecules and specific affinity similar to antibodies. As intracellular molecules are important targets of CPs, quantitation of the intracellular retention and transmembrane permeability of CPs is necessary for drug development. Ho