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Repetitive screening in enterprises was one of the measures recommended in Switzerland in the fight against COVID-19. In the canton of Vaud, 70 companies participated in the program, 73 % of which were small and medium-sized enterprises. The SARS-CoV-2 positivity rate was 0.07 % out of 70'105 tests performed. The impossibility of teleworking and the reduction of transmission were the main motivations for joining the program. The facilitating elements were the availability of the Cantonal Medical Office, the existence of a starter kit and