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These facets position tau as a potentially crucial aspect mediating the disruption of fast axonal transport that precedes synaptic disorder and axonal deterioration at later disease stages. In this chapter, we review evidence that tau affects fast axonal transport and analyze several prospective components proposed to underlie this toxicity.Tau is a microtubule-associated protein (MAP) that is principally sorted to the axons in physiological circumstances, but missorted in Alzheimer Dise
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