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ADHD Stimulant Medication Stimulant drugs are the first line treatment for ADHD. They have a long history of a high response, good tolerance, and are safe throughout the life span. It's important to find the dosage and medication that will relieve your child's or your own symptoms without causing any side effects. It can take a lot of trial and error as well as a constant dialogue with your doctor. Stimulants Stimulants are drugs which increase the activity of the central nervous system. They are wi