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Also, western blot analyzing confirmed that P21 protein overexpressed endogenously after treatment of cells with C3G which it was more upregulated in MG-63 cells compared to the other cell lines. CONCLUSION The final outcomes introduce the C3G as a novel anti-osteosarcoma agent with the ability to induce apoptosis in different osteosarcoma cells via upregulation of the PPARγ and the P21. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] AND PURPOSE Gambogic acid (GA), a promising an
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