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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are the first choice of ADHD drugs, are the ones with the most research behind them, and are quick-acting. But they're not right for everyone. These medications increase the signaling between nerves and regions in the brain, thereby reducing symptoms of ADHD. They can also trigger side effects like a loss of appetite and changes in heart rate or blood pressure. Stimulants The most common medication used to treat ADHD is stimulants.