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The Most Effective ADHD Medication For Adults Adults suffering from ADHD are typically prescribed stimulants. They regulate the levels of two chemical messages in the brain which control the attention. Strattera (atomoxetine) is the most effective adhd medication available for adults. It is a pill or oral capsule that can be taken with or without food. It works well for most people. It lasts longer than stimulants that have a shorter duration of action, such as amphetamine or methylphenidate. 1. Strat