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The effectiveness of both techniques continues to be questionable. We searched MEDLINE, the Cochrane Central enroll of Controlled Trials and Google scholar for observational researches (OS) and randomized controlled tests (RCT) researching vascular closing with the MANTA-based while the ProGlide-based method. The principal endpoint of the evaluation was access-site associated vascular complications. Both research kinds had been examined separately. While OS point to favorable re