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Herein, prostate cancer (PCa)-selective theranostic gold nanoparticles (AuNPs) for accurate cancer imaging and treatment are created. Silicon phthalocyanine, Pc158, ended up being synthesized and deactivated by conjugating it to AuNPs via a biocleavable linker. In vitro and in vivo, the specific AuNPs show exemplary selectivity for PSMA-positive tumor cells. Triggered release of the therapeutic, Pc158, followed by sequential photodynamic therapy (PDT) results in signi