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Here, we show that soluble CD40L (sCD40L) stimulation promotes YY-1 necessary protein phrase and suppresses anti inflammatory cytokine, interleukin 10 (IL-1 appearance in pulmonary adventitial fibroblasts, while YY-1 knockdown stops sCD40L-mediated reduced total of IL-10 appearance via boosting IL-10 gene transactivatiy adventitial fibroblasts. © 2020 International Federation for Cell Biology.Chronic irritation and infection into the tissue su