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01). Five proteins, CD14, A2GL, NID1, SCTM1, and A1AG1, overlapped between both cohorts. Furthermore, after cross-validation, panels of 5 - 12 proteins were able to predict TB up to two years before diagnosis. Host proteins can be biomarkers for increasing Mycobacterium tuberculosis infection activity/burden, incipient TB, and predict TB development in PLHIV. NIH/NIAID AI117927, AI146329, and AI127173 to JMA. NIH/NIAID AI117927, AI146329, and AI127173 to JMA. Protective malarial antibodies are acquired more rapidly in adults than childre