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These mostly negative findings indicate absent or subtle association between salivary cortisol and cognitive decline.Objective To investigate fluid flow through enamel in intact human premolars in vivo and in vitro by using the replica technique. Design The experiments were done on 17 premolars of 10 subjects (aged 10-25 yrs) to be extracted during orthodontic treatment. Teeth were divided into 2 groups. In the first group (n = 11), the fluid accumulated on the enamel surface was recorded with the impression material in the mid-buccal enam