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During days 7-28 PIIBNP was diminished and NITEGE ended up being increased, and during times 35-70 PIIBNP ended up being increased. At end of tradition, the cartilage had sustained proteoglycan content and relative appearance of ACAN less then COL2A1 less then SOX9 less then COL1A1, showing that functional chondrocytes stayed when you look at the explants. Sprifermin induces a temporal biphasic cartilage remodeling in personal knee OA articular cartilage explants, with early
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