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Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that may impact atherosclerosis, and animal experimental studies suggest EETs protect cardiac function. Plasma EETs are mostly esterified to phospholipids and part of an active pool. To address the limited information about EETs and CVD in humans, we conducted a prospective study of total plasma EETs (free+esterified) and diabetes-related CVD in the Cardiovascular Health Study (CHS). We measured 4 EET species and their metabolites, dihydroxyepoxyeicosatrienoic acids (D