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We conclude that the N-methylated analogs of HE and [Formula see text] may be used as a scaffold for the design of a new generation of probes for intra- and extracellular superoxide.Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by early impairment in social and communication domains and autonomic nervous system unbalance. This study evaluated heart rate (HR) as a possible indicator of stress response in children with ASD as compared to children with language disorder (LD). Twenty-four patients [mean age