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How Does Medication For ADHD Work? Most people find that their symptoms improve when they take medication. Finding the right drug at the right dose requires time, open communication and patience with your GP. The medicines that treat ADHD regulate the levels of chemical messengers within the brain. Stimulant drugs, such as methylphenidate can help reduce impulsivity and hyperactivity and help improve concentration. Atomoxetine (Strattera) and Guanfacine (Tenex, Intuniv) are non-stimulant medications t