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PURPOSE To describe the reliability of blood bicarbonate pharmacokinetics in response to sodium bicarbonate (S supplementation across multiple occasions and assess, using putative thresholds, whether individual variation indicated a need for individualised ingestion timings. METHODS Thirteen men (age 27±5 y; body mass (BM) 77.4±10.5 kg; height 1.75±0.06 m) ingested 0.3 g·kgBM SB in gelatine capsules on 3 occasions. One hour after a standardised meal, venous blood was obtained before and every 10 min following ingestion for 3 h, then e