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The relationship between serum prealbumin and the risk of all-cause mortality after hepatectomy in patients with hepatocellular carcinoma (HCC) needs to be evaluated. We conducted a retrospective study. A Cox proportional hazards regression model was used to adjust for potential confounders. Prealbumin level was transformed by Z-scores and categorized into quartiles (Q1 147 mg/L, Q2 147-194 mg/L, Q3 194-239 mg/L, Q4 239 mg/L). We assessed the dose-response relationship between serum prealbumin and the risk of all-cause mortalit