https://www.selleckchem.com/pr....oducts/tj-m2010-5.ht
Background Oral hypoglycemic agents use during pregnancy was assumed to cause fetal macrosomia and skeletal deformities, and maternal complications due to significant transfer across placenta or ineffective control of blood glucose. Objective This study investigated effects of insulin, metformin and glibenclamide on maternal blood glucose; and fetal crown-rump length, gross malformation and pancreatic histology in pregnant streptozotocin-induced diabetic rats. Methods Twenty-five pregnant rats of groups 1 to 5 as normal and diabetic