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y be directly involved in long-distance nitrogen signaling through intercellular interactions. The model predictions and subsequent network analysis identified nitrogen-responsive genes that can be further tested for their specific roles in long-distance nitrogen signaling. The method was developed with the R statistical software and is made available through the R package "irg" hosted on the GitHub repository https//github.com/SMAC-Group/irg where also a running example vignette can be found (https//smac-group.github.io/irg/articles/vi
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