https://www.selleckchem.com/pr....oducts/pf-04418948.h
Background Oxidative stress and protein aggregation are key mechanisms in amyotrophic lateral sclerosis (ALS) disease. Reduced glutathione (GSH) is the most important intracellular antioxidant that protects neurons from reactive oxygen species. We hypothesized that levels of GSH measured by MR spectroscopic imaging (MRSI) in the motor cortex and corticospinal tract are linked to clinical trajectory of ALS patients. Objectives Investigate the value of GSH imaging to probe clinical decline of ALS patients in combination with other neu
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