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The Most Effective ADHD Medication For Adults Most ADHD medications fall into two categories: stimulants or nonstimulants. Stimulants like methylphenidate (Provigil) and amphetamines work by enhancing the activity of parts of the brain that control attention and behaviour. Non-stimulants, such as guanfacine atomoxetine, and clonidine, are slower than stimulants, but they aid in improving focus, attention, and impulsivity. They also help reduce anxiety which is often associated with ADHD in adults. Stimulants The first medication that doctors prescri