https://www.selleckchem.com/pr....oducts/solcitinib.ht
Familial forms of Alzheimer's disease (FAD) are caused by mutations in the gene encoding amyloid precursor protein (APP), whose processing can result in the formation of amyloid β (Aβ). FAD can also result from mutations in the presenilin 1/2 (PSEN1/2) genes, whose protein products partially compose the γ-secretase complex that cleaves Aβ from APP fragments. Psen1-knockout (Psen1-KO) mice and knock-in (KI) mice with homozygous FAD-associated L435F mutations (Psen1LF/LF ) are embryonic and perinatally lethal, precluding a more rigorou
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