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Stimulant Vs Non Stimulant ADHD Medication The most common prescription medication used by healthcare providers to treat ADHD is stimulants. These medications focus on specific brain chemicals, such as dopamine and norepinephrine, to enhance the symptoms of impulsivity as well as inattention. Nonstimulant medicines are an alternative to treatment for those who aren't able to respond to stimulants. They also have less side effects. They target various neurotransmitters and receptors The stimulant medications are usually the first-choice medication fo