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The ability of the ANN models to discriminate 8 month survival with higher accuracy than the respective LR models was further confirmed in 53 consecutive patients. Conclusion We developed ANN models predicting the 8 month survival of unresectable pancreatic cancer patients. These models may help to optimize personalized patient management. Copyright © 2020 Tong, Liu, Ma, Zhang, Lin, Bao, Xu, Gu, Zheng, Liu, Fang, Deng and Zhao.Existing mathematical models for the glucose-insulin (G-I) dynamics often involve variables that are not