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patients receiving the 80 mg dose (27 vs. 0%; p less then 0.001). Conclusions To our knowledge, these are the first cases to highlight a potentially important and serious gastrointestinal complication associated with the 160 mg dose of osimertinib. Copyright © 2020 Patil, Pacheco, Dimou, Purcell, Rossi, Bunn, Doebele, Camidge and Ferrigno.Soft tissue sarcomas (STS) are heterogeneous rare malignancies comprising ~1% of all solid cancers in adults and including more than 70 histological and molecular subtypes with different pathological