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This review will describe the part of CD47 in myeloid malignancies and pre-clinical information encouraging CD47 targeting. In addition, preliminary clinical information of CD47 targeting in AML/MDS are reviewed, and such as the first-in-class anti-CD47 antibody magrolimab. Copyright © 2020 Chao, Takimoto, Feng, McKenna, Gip, Liu, Volkmer, Weissman and Majeti.Emerging details of the gene expression and mutational attributes of canine lymphoma and leukemia prove regions of similarities and