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In conclusion, aerobic exercise reversed the change of dendritic morphology and increased the synaptic plasticity-related protein expression in the hippocampus and cerebral cortex of OVX mice. The positive effects induced by exercise might be mediated through the BDNF-mTOR signaling pathway.Cohen syndrome is caused by homozygous mutation in the vacuolar protein sorting 13 homolog B (VPS13B, also referred to as COH1) gene on chromosome 8q22.2. The VPS13B protein is involved in transmembrane transport, Golgi integrity, and neuritogenesis. C