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Tyrosine metabolic rate, purine metabolism, isoquinoline alkaloid biosynthesis and terpenoid backbone biosynthesis were changed in origins by PFOA and PFOS. Tricarboxylic acid pattern was perturbed by 5000 ng/L visibility. Activation of anti-oxidant security pathways, reallocation of carbon and nitrogen k-calorie burning, legislation of power metabolism and purine metabolism were reprogrammed in roots. Lettuce employed multiple strategies to boost threshold to PFOA and PFOS, which include