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Making use of meningioma cells and in vitro models, we investigated microRNA levels in meningioma samples of different grades, in addition to their particular legislation. Considering this, we additionally investigated prospect miRNAs appearance in serum, and their prospective as biomarkers. We discovered that miR-497~195 group expression in meningioma decreases with increasing malignancy class, and that Cyclin D1 overexpression correlated with downregulation for the miR-49