https://www.selleckchem.com/pr....oducts/mi-773-sar405
We find no evidence for stable oligomers of RHBDL2 in giant plasma membrane vesicles of human cells even at concentrations that highly exceed endogenous expression levels. This indicates that the rhomboid transmembrane core is intrinsically monomeric. Our findings will find use in the application of FRET and fluorescence correlation spectroscopy for the analysis of oligomerization of transmembrane proteins in cell-derived lipid membranes. Laurdan fluorescence, novel spectral fitting, and dynamic light scattering were combined t
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