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9±8.9 to 17.6±9.4; MMRC 3±0.7 to 2.2±1.1, LCADL 38±13.9 to 31.6±11; p0.0001). Using the distribution-based analysis, MID of -2.67 (standard error of measurement) or -4.45 (standard deviation) was found. According to methodology, we could only use SGRQ as anchor. With SGRQ as anchor, the receiver operating characteristic curve identified MID for the change in D-12 at -6.1 (sensibility 58%, specificity 79%). The correlation with SGRQ was modest (r=0.33), so the calculated MID should be interpreted with caution. D-12 is a good tool to
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