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The results showed that SPI could potentially be used as a novel health strategy to reduce the harm of AA in the human body. In this study, we describe a newly excavated early Holocene human cranium from Guizhou, Southwestern China, namely the Zhaoguo M1 (ZG 1). We aim to evaluate its morphological resemblance with Late Pleistocene human, and Northern and Southern China Neolithic populations. We also aim to infer its position in the process of East Asian population regionalization. The ZG 1 skull is almost complete, only missing parts of th