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Most importantly, we found that the combined use of density and height, i.e. volume, considerably increased mapping quality in general and with regard to regional discrepancy by largely eliminating systematic underestimation in dense agglomerations and overestimation in rural areas. We also found that building density, type and volume, together with living floor area per capita, are suitable to produce accurate large-area bottom-up population estimates.During influenza epidemics, Japanese clinicians routinely conduct rapid influenza di