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s study, the performance of the models for other chemicals could be investigated, to improve the accuracy of the simulations. Previous studies of prenatal phthalate exposure and childhood asthma are inconsistent. These studies typically model phthalates as individual, rather than co-occurring, exposures. We investigated whether prenatal phthalates are associated with childhood wheeze and asthma using a mixtures approach. We studied dyads from two prenatal cohorts in the ECHO-PATHWAYS consortium CANDLE, recruited 2006-2011 and TIDES, rec