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Apart from the cheap price, large portability, and disposability, the CC-ESwe had merits of quantitation capacity along with sufficient sensitivity. By coupling CC-ESI to a miniature mass spectrometer (mini-MS), a limit of detection (LOD) of just one ng/mL had been achieved for standard imatinib at collision-induced dissociation (CID) combination MS mode, and a LOQ of 1 ng/mL was obtained for atenolol and imatinib (with isotopic inner standard) at several ion reaction monitoring (MRM) settings. As two demonstrations for evaluation of pr
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