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To describe development of the Positive Affect, Promoting Positive Engagement, and Adherence for Life (APPEAL) program. APPEAL is intended to increase HIV medication adherence through promotion of positive affect, and was developed through an iterative process involving 6 focus groups (N = 34) that elicited feedback on intervention content, followed by an individually administered prepilot of the entire intervention (N = 7). Participants provided feedback on important potential moderator variables, including depression, on mode of inter