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These principles can not only guide efforts toward a safe and effective COVID-19 vaccine, but also the development of effective vaccines for viral pandemics to come. The Kingdom of Saudi Arabia was hit hard by the COVID-19 pandemic wave. King Faisal Specialist Hospital and Research Centre, Riyadh dealt with the crisis in a proactive way with the emergency department (ED) playing a pivotal role. We searched the international literature to review the processes adopted by healthcare institutions and also used our experience of managing a p