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ADHD Medication UK For Adults The first medication prescribed is typically a stimulant such as methylphenidate. It stimulates the parts of the brain that regulate attention and behaviour. Adults with ADHD are more likely to benefit from long-acting formulations. They build up slowly in the bloodstream, avoiding the 'crash" that can occur when short-acting medication wears off. Stimulants Stimulants are among the most commonly prescribed treatment for ADHD and increase levels of dopamine and