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This paper can compensate for the lack of research on the UPI effect at the local level and provide scientific evidence for air pollution control during urban agglomeration planning.Cocaine-induced plasticity in the glutamatergic transmission and its N-methyl-d-aspartate (NMDA) receptors are critically involved in the development of substance use disorder. The presynaptic active zone proteins control structural synaptic plasticity; however, we are still far from understanding the molecular determinants important for cocaine seeking beh