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Non Stimulant ADHD Medication Stimulants raise dopamine and neurotransmitters norepinephrine and norepine that aid in motivation and alertness, concentration and effort. They can also enhance focus and concentration. Non-stimulant ADHD medications are usually prescribed when stimulants don't work and cause unacceptably adverse negative side effects or when a patient cannot take them due to medical reasons. Clonidine (Kapvay), and guanfacine (Intuni