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Glucocorticoids and the GR serve as an essential molecular mediator of stress and different physiologic processes. This review summarizes main findings from studies on the role of the GC/GR signaling in the modulation of genes for nutrient processing by the different organs involved in metabolic diseases. Descriptive review of relevant papers known to the author was conducted. Several high-throughput screenings in the past 15 years have identified potential GR DNA-binding regions in different cell types with genes that are