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Studies 1 and 2 measured positive and negative feelings about medications, risk perceptions, and likelihood of taking medications. Across both studies, gain-framed attributes led to more positive integral affect, subsequently increasing likelihood to take medications, whereas loss-framed attributes led to more negative feelings and increased perceived riskiness of medications. Study 2 found that positive affective contexts indirectly led to an increased likelihood to take medication by increasing positive feelings about the medications.