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It has been proved that the mechanical and frictional properties of Ti-Cu alloys can be adjusted by changing the Cu content, so as to better meet its application in the medical field.With interest, we read the article by Jonak et al [...].There is currently no effective pharmacological therapy to improve the cognitive dysfunction of individuals with Down syndrome (DS). Due to the overexpression of several chromosome 21 genes, cellular and systemic oxidative stress (OS) is one of the most important neuropathological processes that contri