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We finally discussed the practical implications of these aspects and role of additional potentially relevant factors to be explored. Final purpose was to provide a guideline helpful in promoting increase in the extent of tumor resection while preserving the patients' neurological and cognitive functioning. Cure rates for pediatric acute lymphoblastic leukemia (ALL) have reached an all-time high (90%); however, neurocognitive difficulties continue to affect quality of life in at least a subset of survivors. There are relatively few
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