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Third-Variable effect refers to the intervening effect from a third variable (called mediators or confounders) to the observed relationship between an exposure and an outcome. The general multiple third-variable effect analysis method (TVEA) allows consideration of multiple mediators/confounders (MC) simultaneously and the use of linear and non-linear predictive models for estimating MC effects. Previous studies have found that compared with non-Hispanic White population, Blacks and Hispanic Whites suffered disproportionally more with ob