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Network biology analysis showed LRRK2, DRD2, IGF-1, GNAI1, GNAI3, PRKACA, PPP2R5C, and PIK3R1 play a major role in protein regulation of PD. Therefore, HP and ST play more important roles in the development of PD and it is also suggested the potential target gene for diagnosis and treatment of PD.It is crucial to reveal the variability between patients with epilepsy and healthy subjects to elucidate the underpinnings of the disease pathology. Herein, we assessed the inter-subject variability between patients with temporal lobe epilepsy (