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modeling unveiled a reduced communication between mutant AGT and renin. One patient survived after answering high-dose hydrocortisone therapy, with quality of powerful hypotension, accompanied by an increase in serum AGT, Ang we, and Ang II amounts. Substudy 1 was a single-arm open-label study of 12 weekly infusions and tapered corticosteroids, with 6 weeks of follow-up. In substudy 2, patients had been randomized 11 to receive a program of treatment consisting of once-wee