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05). Conversely, niacin decreased the ratios of propionate/acetate and butyrate/acetate in the colonic contents of weaned piglets (P less then 0.05); Interestingly, niacin increased the protein expression of SIRT1 (P less then 0.05) and inhibited the protein expression of HDAC7 (P less then 0.05). In conclusion, niacin attenuated the weight loss and diarrhea, and improved the expression of antimicrobial peptides, and enhanced intestinal epithelial barrier function, and improved the microbiota in the colonic contents of weaned piglets, s