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The goal of this study was to evaluate differences in clinical and patient-reported outcomes between women and men hospitalized for acute HF. Among patients hospitalized for heart failure (HF), it is unclear if symptom burden, response to therapy, and patient-reported quality of life (QOL) are different in women as compared with men. The ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated HeartFailure) trial randomized 7,141 patients hospitalized for HF with reduced or preserved ejection fraction (EF) to recei